One of the world's largest pharmaceutical companies, Roche sells its products in over 100 countries. Roche's prescription drugs include cancer therapies MabThera/Rituxan and Avastin, Perjeta and Kadcyla for HER2-positive breast cancer, idiopathic pulmonary fibrosis drug Esbriet, macular degeneration therapy Lucentis, and Tamiflu, which is used for infectious diseases. The company markets many of its bestsellers through California-based subsidiary Genentech and Japanese affiliate Chugai Pharmaceutical. Roche's diagnostics arm offers clinical lab supplies, genetic tests, diabetes monitoring supplies, and point-of-care diagnostics for health care providers. Roche records among the world's highest pharmaceutical R&D spend annually and generates majority of sales from North America.